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Richter transformation stays an ominous function for individuals with CLL, notably when it truly is clonally associated with the original CLL, mainly because none of the not too long ago authorized novel agents is really effective. In fact, disease transformation is a relatively prevalent cause of failure to benefit from these medication.ninety,128,129 Histological affirmation is often suggested as it can guide prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have more favorable prognosis).
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First chromosome banding Examination uncovered that deletions or trisomies had been rather widespread but only observed in much less than 50 % of the patients.forty six With the arrival of fluorescent in situ
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